In this post, I provide the facts on Kelo-Cote vs Mederma, including key ingredients, clinical studies, customer reviews, and my personal experience.
Overall, I recommend Kelo-Cote Scar Gel for "high risk scars" like hypertrophic scars and keloids from severe burns, surgery / post-op, car accidents, and acne scars, and Mederma Advanced Scar Gel for "low risk scars" like kitchen burns, minor cuts & scrapes, and small bruises.
✅ Best For: High Risk Scars
✅ Key Ingredient: Silicone
✅ Application: 2x Daily
✅ Clinical Evidence: Strong
✅ Side Effects: None
✅ Reviews: 1,500+
✅ Price/Value: Good
✅ Best For: Low Risk Scars
✅ Key Ingredient: Onion Extract
✅ Application: 1x Daily
⚠️ Clinical Evidence: Mixed
❌ Side Effects: Itchiness, Redness
✅ Reviews: 16,000+
✅ Price/Value: Very Good
💡 Here's the key difference between Kelo-Cote and Mederma:
Kelo-Cote is a very affordable silicone gel made by UK-based Alliance Pharma Plc that has shown strong clinical evidence for scar treatment while Mederma is a very popular and affordable onion extract gel made by German manufacturer Merz Pharmaceuticals GmbH that has shown mixed clinical evidence for scar treatment.
Kelo-Cote is a brand of silicone-based products (primarily silicone gels and a silicone spray), that are used to treat hypertrophic scars and keloids from burns, surgery, wounds, and acne.
The brand has been owned by different companies in the past, including its original inventor, Advanced Bio-Technologies, followed by Enaltus, Sinclair Pharma, and Alliance Pharma.
Based on my independent research, Kelo-Cote is currently distributed by Enaltus LLC in the US and Alliance Pharma Plc in non-US markets including Europe and the Asia-Pacific.
That's because Sinclair Pharma Plc originally acquired the non-US distribution rights from Advanced Bio-Technologies in 2011, and a few years later, Alliance Pharma Plc acquired the healthcare business of Sinclair in 2015, including its Kelo-Cote distribution rights.
This is why you might see two (or even three) different types of Kelo-Cote on Amazon.
I know, it's definitely a bit confusing! 🤔
Here's an example of the most recent Kelo-Cote package by Alliance Pharma:
You'll find the Alliance Pharma version available on Amazon.com (even though the listing still says Sinclair Kelo-Cote). The older version by Sinclair Pharma is still floating around as well:
Finally, the US version by Enaltus LLC has a distinctly different design:
As far as I know, the actual Kelo-Cote formula is the same across all three versions and this is confirmed in an internal company document (the "Kelo-Cote difference"), which states the "original formulation of the Kelo-Cote brand has not changed since issue of US patent in 1998".
If you're still shopping around, though, I recommend these silicone gels as well:
NewGel+ is one of my preferred silicone gels as it has a very smooth gel texture and includes bonus vitamin E to help moisturize and soften your scars.
NewGel+ is manufactured by NewMedical Technology, Inc., the same company behind the premium silicone gel, Silagen.
While NewGel+ is not cheap at ~$54 per oz, I personally like the formula better and have seen good results for my own scars (NewGel+ has over 500 reviews on Amazon as well).
If you're looking for the cheapest silicone gel, Aroamas is only ~$30 per oz and has received thousands of reviews on Amazon.
I haven't personally tried Aroamas yet but it's amazing value for money at this price.
On the other hand, Mederma Advanced Scar Gel is an excellent option for low risk scars like kitchen burns, minor cuts & scrapes, and small bruises.
That's because some studies have shown that Mederma helps minimize new scar formation (Draelos, 2012) and it's much more affordable than silicone gels at ~$16 per oz.
However, the clinical evidence is still mixed and inconclusive, whereas silicone gel has been proven time and time again by randomized clinical trials (RCTs) and medical reviews.
Overall, if you are concerned about your scar's appearance, I recommend using a silicone gel like Kelo-Cote or NewGel+ 2x a day for at least 3-6 months to give your skin the best chance of achieving an optimal recovery outcome following an injury or surgical procedure.
However, if you have an old scar like a mature keloid (2+ years), you may want to speak to your dermatologist about corticosteroid injections as well, as I've personally found them very helpful for flattening my keloid scars and gradually restoring more normal skin color.
P.S. I've personally tried almost every silicone gel on the market, including ScarAway, Kelo-Cote, NewGel+, Hiruscar, Strataderm, and Azally. Check out my full review here.
✅ Hypertrophic Scars
✅ Surgery / Post-Op
✅ Acne Scars
⭐ Medical Grade Silicone
👍 Available in 15g / 30g
👍 2x Daily Application
👍 Transparent & Odorless
👍 Water Resistant
👍 No Side Effects
🕓 3-6 Months (New Scars)
🕓 6+ Months (Old Scars)
Are you searching for the best scar treatment?
(Me too! That's why I started The Derm Detective 🕵️♂️)
While there's plenty of scar creams on the market, did you know that the #1 recommended over-the-counter (OTC) scar treatment is medical grade silicone?
In fact, an international advisory panel of the world's leading dermatologists and plastic surgeons unanimously recommended silicone products for scar management. (source: Dermatologic Surgery, 2014)
Silicone forms a unique semi-permeable barrier that protects your scar from infection, keeps it hydrated by preventing water loss, while allowing oxygen exchange.
This helps minimize scar formation as research shows that dehydrated skin cells produce inflammatory signals that stimulate excess collagen production, resulting in raised, red, and thick bands of scar tissue like keloids. (source: Advances in Wound Care, 2015)
If you're interested, here's an excellent video on scar formation and how silicone works:
Now that you know how silicone works in theory, how effective is it in practice?
Since its introduction in the 1980s, there's been hundreds of clinical studies on silicone gel and silicone gel sheets.
Fortunately, Hsu et al. (2017) and Wang et al. (2021) have reviewed the medical literature and concluded that silicone is statistically more effective than placebos or no treatment:
Now that you're up to speed, let's finally discuss Kelo-Cote Scar Gel.
However, price is not the only consideration because ultimately, it's the results that matter.
I've personally used Kelo-Cote (the Alliance Pharma version) on my chest keloids and I noticed that it has a transparent and watery texture, compared to the thick, sticky, and cream-like consistency of competing silicone gels like Strataderm or NewGel+.
After doing more research, I believe this is because Kelo-Cote uses a patented formulation (recently expired in 2016) of long chain polymers and silicon dioxide that allows it to dry quickly to form a silicone sheet on the surface of your skin.
According to Alliance Pharma, the effectiveness of Kelo-Cote for scar management has been demonstrated in 10 clinical trials as well.
In any case, I personally didn't see a tremendous improvement in scar appearance, however, my hypertrophic scars and keloids are very mature (5+ years) and occur in high-risk areas like the presternum (upper chest) which are notoriously less responsive to topical treatments.
In other words, I'd still recommend giving Kelo-Cote a shot, given its unique silicone formula, long history of operations, and thousands of customer reviews.
My Verdict: If you have high risk scars (e.g. hypertrophic scars or keloids from burns, surgery, trauma, acne, or you have a family history of keloids), use a silicone gel like Kelo-Cote to minimize scar formation, promote post-op recovery, and reduce itchiness and redness.Shop Now
❌ High Risk Scars
✅ Low Risk Scars
✅ Mild Burns
✅ Cuts & Scrapes
✅ Minor Injuries
⭐ Onion Bulb Extract
⭐ Hyaluronic Acid
👍 1x Daily Application
👍 Gel Texture
👍 Mild Fragrance
🕓 4-8 Weeks (New Scars)
🕓 3-6 Months (Old Scars)
With 16,000+ reviews, there's definitely no question that Mederma is the most popular scar treatment (currently the #1 Bestseller in Scar Reducing Treatments).
But does Mederma really work on scars? 🤔
Before I provide you the answer, let me first tell you that I've personally used Mederma for 6+ months, reviewed the original clinical study in 2012 by Dr. Draelos, and consulted the medical literature on scar treatment.
In addition, I'd like you to keep in mind that everyone scars and heals differently, as genetics play a key role in how your body recovers from a wound.
For example, people with a family history of keloids are more likely to develop keloids themselves (1/3 of people with keloids have a first-degree relative with keloids).
In short, use Mederma on "low risk" scars only.
Low risk scars are defined in the International Clinical Recommendations on Scar Management as:
In other words, I recommend using Mederma for less serious wounds, such as mild burns, cuts & scrapes, bruises & accidents, and other minor injuries.
That's because the key ingredient in Mederma Advanced Scar Gel is onion bulb extract (a.k.a. Cepalin in Mederma's marketing materials and allium cepa in the ingredient list).
According to the 2014 International Clinical Recommendations on Scar Management (Part 2), a highly influential research paper authored by the world's leading experts on scar treatment, there's conflicting evidence on the effectiveness of onion extract for scars.
Some studies showed positive evidence, like the original clinical trial by Draelos et al. (2012) that was sponsored by Merz Pharmaceuticals (the parent company of Mederma).
In short, this study found a statistically significant difference in scar appearance between Mederma-treated scars (test group) and non-treated scars (control group) after 4-8 weeks.
However, there's a number of major flaws with this study:
Other studies found that onion extract was no better than similar topical treatments but resulted in more frequent side effects (itchiness, redness) that caused patients to stop using it. (source: International Wound Journal, 2021)
In addition, many studies used multiple active ingredients in their formulations which made it more difficult to isolate the effects of onion extract. (source: Dermatologic Surgery, 2014)
Finally, here's my personal opinion of Mederma Advanced Scar Gel based on 6+ months of using it on my chest keloids:
My Verdict: Taking into account the key ingredients, clinical studies, and my own experience, I recommend Mederma Advanced Scar Gel for low risk scars as the medical evidence is mixed. Mederma may help minimize scars from minor injuries and accelerate the recovery process.Shop Now