In this post, I provide the facts on Strataderm vs Mederma, including key ingredients, clinical studies, customer reviews, and my personal experience.
Overall, I recommend using Strataderm Scar Therapy Gel for "high risk scars" like hypertrophic scars and keloids from severe burns, surgery, car accidents, and acne, while using Mederma Advanced Scar Gel for "low risk scars" like kitchen burns, minor cuts & scrapes, and small bruises.
✅ Best For: High Risk Scars
✅ Key Ingredient: Silicone
✅ Application: 1x Daily
✅ Clinical Evidence: Strong
✅ Side Effects: None
✅ Reviews: 900+
✅ Price/Value: Reasonable
✅ Best For: Low Risk Scars
✅ Key Ingredient: Onion Extract
✅ Application: 1x Daily
⚠️ Clinical Evidence: Mixed
❌ Side Effects: Itchiness, Redness
✅ Reviews: 16,000+
✅ Price/Value: Very Good
💡 Here's the key difference between Strataderm and Mederma:
Strataderm is a high-quality silicone gel made by Swiss manufacturer Stratpharma AG that has shown strong clinical evidence for scar treatment while Mederma is a very popular and affordable onion extract gel made by German manufacturer Merz Pharmaceuticals GmbH that has shown mixed clinical evidence for scar treatment.
Strataderm is a premium silicone gel made by Switzerland-based manufacturer Stratpharma that's sold by medical professionals like dermatologists and plastic surgeons, as well as online through the official Stratpharma website or third-party retailers like Amazon.
I personally bought the 50g version last year and it's lasted me almost a year now with daily use!
Silicone gels and silicone sheets have been the gold standard of scar treatment for decades and are recommended in the International Clinical Recommendations on Scar Management. (source: Dermatologic Surgery, 2014)
In particular, a silicone gel helps reduce the appearance of hypertrophic scars and keloids from burns, surgery, car accidents, and acne, including the size, height, and color of scars.
Currently, you can buy 50 g (1.75 oz) of Strataderm for US$109.95 from the official Stratpharma website (for international customers, visit your respective regional store).
This works out to ~$62 per oz, making Strataderm one of the more expensive silicone gels.
If you check Amazon.com, you'll find that Strataderm 50 g is sometimes sold at a lower price, resulting in ~$50 per oz. (still a bit expensive, but much more reasonable)
For a more affordable option, I recommend the following silicone gels:
NewGel+ is one of my preferred silicone gels as it has a very smooth gel texture and includes bonus vitamin E to help moisturize and soften your scars.
NewGel+ is manufactured by NewMedical Technology, Inc., the same company behind the premium silicone gel, Silagen.
While NewGel+ is not exactly cheap at ~$54 per oz, it's a better deal if you only need a 1 oz tube instead of the Strataderm 50 g version (which is only cheaper on a per oz basis).
If you're looking for the cheapest silicone gel, Aroamas is only ~$30 per oz and has received thousands of reviews on Amazon.
I haven't personally tried Aroamas yet but it's amazing value for money at this price.
On the other hand, Mederma Advanced Scar Gel is an excellent option for low risk scars like kitchen burns, minor cuts & scrapes, and small bruises.
That's because some studies have shown that Mederma helps minimize new scar formation (Draelos, 2012) and it's much more affordable than silicone gels at ~$16 per oz.
However, the clinical evidence is still mixed and inconclusive, whereas silicone gel has been proven time and time again by randomized clinical trials (RCTs) and medical reviews.
Overall, if you are concerned about your scar's appearance, I recommend using a silicone gel like Strataderm or NewGel+ 2x a day for at least 3-6 months to give your skin the best chance of achieving an optimal recovery outcome following an injury or surgical procedure.
However, if you have an old scar like a mature keloid (2+ years), you may want to speak to your dermatologist about corticosteroid injections as well, as I've personally found them very helpful for flattening my keloid scars and gradually restoring more normal skin color.
P.S. I've personally tried almost every silicone gel on the market, including ScarAway, Kelo-Cote, NewGel+, Hiruscar, Strataderm, and Azally. Check out my full review here.
✅ Hypertrophic Scars
✅ Surgery / Post-Op
✅ Acne Scars
⭐ Medical Grade Silicone
👍 Available in 5-50g
👍 1x Daily Application
👍 Transparent & Odorless
👍 Water Resistant
👍 No Side Effects
🕓 3-6 Months (New Scars)
🕓 6+ Months (Old Scars)
Are you searching for the best scar treatment?
(Me too! That's why I started The Derm Detective 🕵️♂️)
While there's plenty of scar creams on the market, did you know that the #1 recommended over-the-counter (OTC) scar treatment is medical grade silicone?
In fact, an international advisory panel of the world's leading dermatologists and plastic surgeons unanimously recommended silicone products for scar management. (source: Dermatologic Surgery, 2014)
Silicone forms a unique semi-permeable barrier that protects your scar from infection, keeps it hydrated by preventing water loss, while allowing oxygen exchange.
This helps minimize scar formation as research shows that dehydrated skin cells produce inflammatory signals that stimulate excess collagen production, resulting in raised, red, and thick bands of scar tissue like keloids. (source: Advances in Wound Care, 2015)
If you're interested, here's an excellent video on scar formation and how silicone works:
Now that you know how silicone works in theory, how effective is it in practice?
Since its introduction in the 1980s, there's been hundreds of clinical studies on silicone gel and silicone gel sheets.
Fortunately, Hsu et al. (2017) and Wang et al. (2021) have reviewed the medical literature and concluded that silicone is statistically more effective than placebos or no treatment:
Now that you're up to speed, let's finally discuss Strataderm Scar Therapy Gel.
However, price is not the only consideration because ultimately, it's the results that matter.
With silicone gels, it's difficult to tell the difference in product quality without using the product because every manufacturer will say they use 100% medical grade silicone.
I suspect that premium silicone gels like Strataderm and Silagen use a higher quality silicone, but this is not explicitly stated.
From my experience using Strataderm on my hypertrophic scars and keloids, I've found that it has a thicker, almost cream-like, consistency, whereas cheaper silicone gels like ScarAway and Kelo-Cote are almost always clear/transparent with a more liquid-like consistency.
Overall, if you plan to buy Strataderm, make sure to buy an authentic product from your dermatologist's office, the official Stratpharma website, or a reputable third-party seller.
My Verdict: If you have high risk scars (e.g. hypertrophic scars or keloids from burns, surgery, trauma, acne, or you have a family history of keloids), use a silicone gel like Strataderm to minimize scar formation, promote post-op recovery, and reduce itchiness and redness.Shop Now
❌ High Risk Scars
✅ Low Risk Scars
✅ Mild Burns
✅ Cuts & Scrapes
✅ Minor Injuries
⭐ Onion Bulb Extract
⭐ Hyaluronic Acid
👍 1x Daily Application
👍 Gel Texture
👍 Mild Fragrance
🕓 4-8 Weeks (New Scars)
🕓 3-6 Months (Old Scars)
With 16,000+ reviews, there's definitely no question that Mederma is the most popular scar treatment (currently the #1 Bestseller in Scar Reducing Treatments).
But does Mederma really work on scars? 🤔
Before I provide you the answer, let me first tell you that I've personally used Mederma for 6+ months, reviewed the original clinical study in 2012 by Dr. Draelos, and consulted the medical literature on scar treatment.
In addition, I'd like you to keep in mind that everyone scars and heals differently, as genetics play a key role in how your body recovers from a wound.
For example, people with a family history of keloids are more likely to develop keloids themselves (1/3 of people with keloids have a first-degree relative with keloids).
In short, use Mederma on "low risk" scars only.
Low risk scars are defined in the International Clinical Recommendations on Scar Management as:
In other words, I recommend using Mederma for less serious wounds, such as mild burns, cuts & scrapes, bruises & accidents, and other minor injuries.
That's because the key ingredient in Mederma Advanced Scar Gel is onion bulb extract (a.k.a. Cepalin in Mederma's marketing materials and allium cepa in the ingredient list).
According to the 2014 International Clinical Recommendations on Scar Management (Part 2), a highly influential research paper authored by the world's leading experts on scar treatment, there's conflicting evidence on the effectiveness of onion extract for scars.
Some studies showed positive evidence, like the original clinical trial by Draelos et al. (2012) that was sponsored by Merz Pharmaceuticals (the parent company of Mederma).
In short, this study found a statistically significant difference in scar appearance between Mederma-treated scars (test group) and non-treated scars (control group) after 4-8 weeks.
However, there's a number of major flaws with this study:
Other studies found that onion extract was no better than similar topical treatments but resulted in more frequent side effects (itchiness, redness) that caused patients to stop using it. (source: International Wound Journal, 2021)
In addition, many studies used multiple active ingredients in their formulations which made it more difficult to isolate the effects of onion extract. (source: Dermatologic Surgery, 2014)
Finally, here's my personal opinion of Mederma Advanced Scar Gel based on 6+ months of using it on my chest keloids:
My Verdict: Taking into account the key ingredients, clinical studies, and my own experience, I recommend Mederma Advanced Scar Gel for low risk scars as the medical evidence is mixed. Mederma may help minimize scars from minor injuries and accelerate the recovery process.Shop Now