Dermatix vs Mederma 2019 | What’s Better for Scars?

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Dermatix vs Mederma

Do you need help deciding between Dermatix and Mederma for scar treatment?

Lucky for you, I’ve put together a full comparison of Dermatix vs Mederma.

Dermatix is an effective silicone gel while Mederma is a popular onion extract gel.

You’re probably wondering, “So which one is better?”

Well…

The short version is: Dermatix.

You see, onion extract gels like Mederma are promising, but not yet supported by the medical community for scar therapy due to mixed clinical evidence. (1)

Silicone gels, on the other hand, are backed by decades of clinical research and recommended for hypertrophic scars and keloids by both dermatologists and plastic surgeons.

There are many brands of silicone gels, including Dermatix Ultra (made in Europe).

My personal recommendation for a silicone gel is NewGel+ (I use this one myself).

Related:

Dermatix vs Mederma

Preview
Best for Scar Discoloration
Dermatix Ultra - Advanced Scar Formula Innovative CPX Technology & Unique Vitamin C Ester 15g
Best Budget Option
Mederma Advanced Scar Gel - 1x Daily - Reduces The Appearance of Old & New Scars - #1 Doctor & Pharmacist Recommended Brand for Scars - 1.76oz.
Editor's Top Pick
NewGel+ Advanced Silicone Gel for Scars, 1 Ounce
Product Name
Dermatix Ultra Advanced Scar Formula
Mederma Advanced Scar Gel
NewGel+ Advanced Silicone Gel for Scars
Product Size
15 g
50 g
30 g
Recommended for Scars?
Active Ingredients
Cyclopentasiloxane (Silicone), Blend of Silicone Polymers, Tetrahexyldecyl Ascorbate (Vitamin C Ester)
Cepalin® (Onion Extract Gel)
Polymerized Siloxanes (Silicone), Vitamin E
Application Frequency
2x Daily
1x Daily
2x Daily
Customer Rating
Prime Eligibility
Price
$35.50
$28.80
$54.00
Best for Scar Discoloration
Preview
Dermatix Ultra - Advanced Scar Formula Innovative CPX Technology & Unique Vitamin C Ester 15g
Product Name
Dermatix Ultra Advanced Scar Formula
Product Size
15 g
Recommended for Scars?
Active Ingredients
Cyclopentasiloxane (Silicone), Blend of Silicone Polymers, Tetrahexyldecyl Ascorbate (Vitamin C Ester)
Application Frequency
2x Daily
Customer Rating
Prime Eligibility
Price
$35.50
More Information
Best Budget Option
Preview
Mederma Advanced Scar Gel - 1x Daily - Reduces The Appearance of Old & New Scars - #1 Doctor & Pharmacist Recommended Brand for Scars - 1.76oz.
Product Name
Mederma Advanced Scar Gel
Product Size
50 g
Recommended for Scars?
Active Ingredients
Cepalin® (Onion Extract Gel)
Application Frequency
1x Daily
Customer Rating
Prime Eligibility
Price
$28.80
More Information
Editor's Top Pick
Preview
NewGel+ Advanced Silicone Gel for Scars, 1 Ounce
Product Name
NewGel+ Advanced Silicone Gel for Scars
Product Size
30 g
Recommended for Scars?
Active Ingredients
Polymerized Siloxanes (Silicone), Vitamin E
Application Frequency
2x Daily
Customer Rating
Prime Eligibility
Price
$54.00
More Information

Last Updated: 2020-04-05 / Images from Amazon PA API

Our Recommendations

Dermatix is a brand of silicone gels made by a European manufacturer.

Silicone gels are clinically proven to reduce scars and recommended by the International Advisory Panel on Scar Management for both hypertrophic scars and keloids. (1)

Unlike other scar products, silicone gels are lightweight, odorless, and do not cause side effects like itchiness or skin discoloration (issues that I’ve found with Mederma).

Silicone gels are also easy to apply. 

To be fair, I’ve had some success with Mederma before for my chest keloids (see here).

But after 6 months, I stopped using Mederma due to side effects like itchiness and skin discoloration. I’ve since switched to NewGel+ and haven’t experienced any side effects.

To Wrap Up:

If you want the best results for your scars, stick with a silicone gel like NewGel+ or Dermatix.

If you have less severe scars or are on a tight budget, Mederma is a great option.

Dermatix Ultra Advanced Scar Formula

A brand of silicone gels made in Europe for hypertrophic scars and keloids.

PROS

  • Reduces scar height & size
  • Restores normal skin color
  • Helps fade dark spots
  • Easy to apply
  • Great reviews

CONS

  • Results require patience
  • A bit expensive compared to other silicone gels

Dermatix is a brand of silicone gels made in Europe. The product claims to leverage an innovative silicone technology (cyclopentasiloxane) to produce a thin and lightweight film.

Silicone is clinically proven to improve scar appearance and skin discoloration. (1)

It works by keeping your skin hydrated, which in turn prevents collagen production, a major contributor to hypertrophic scar and keloid formation. 

Dermatix is thin, clear, and odorless, making it easy to apply and leave on your skin.

It also includes vitamin C, an ingredient known to improve dark spots and hyperpigmentation.

Key Features

  • 100% medical grade silicone gel
  • Thin, clear, and odorless
  • Fast drying
  • Includes vitamin C

Key Benefits

  • Flattens existing scars
  • Prevents new scars
  • Reduces skin discoloration
  • Improves dark spots and hyperpigmentation
  • Easy to apply

Suitable For

  • Hypertrophic scars
  • Keloids (including on the chest or earlobes)
  • Surgical scars (including C-section)
  • Scars from trauma, burns, or injuries
  • Scars on the face, hands, and other visible areas

Why Silicone?

Silicone is the #1 dermatologist and plastic surgeon recommended over-the-counter scar reduction ingredient, according to an independent market research firm. (2)

In 2014, the International Advisory Panel on Scar Management confirmed the clinical efficacy of silicone for the treatment of hypertrophic scars and keloids. (1)

Researchers believe that silicone works by hydrating and protecting the scar. This prevents skin dehydration which can contribute to abnormal scar formation. (3)

Dermatix Reviews

Among the positive reviews, many people claimed Dermatix reduced their scar appearance, including scar size, scar height, and skin discoloration.

Among the negative reviews, some people didn’t notice any results after using Dermatix. Others noted that the product is manufactured in the USA but shipped from Thailand, which is a bit of a puzzling story.

To be fair, most people don’t use the product long enough to see the desired results. In my experience, it can take between 3-6 months to see any noticeable improvements in your scars. 

The Bottom-Line

Dermatix Ultra is a good brand of silicone gels.

For the best value, however, I recommend NewGel+ (my top pick and the one I use).

NewGel+ is effective, easy to ​apply, and reasonably priced.

Mederma Advanced Scar Gel

PROS

  • Softens existing scars
  • Reduces discoloration
  • Thousands of reviews
  • Affordable

CONS

  • Inconclusive clinical studies
  • Results require patience
  • May cause itchiness, irritation, or redness

About Mederma

If you want great results that won’t break the bank, Mederma is an excellent option.

Featuring Cepalin (onion extract), Mederma has been the #1 pharmacist recommended brand for 15 years.

Although clinical studies of onion extract are somewhat mixed, it’s clear that Mederma has helped thousands of people with their scar problems.

Amazon alone has well over 2,000 reviews, including hundreds of before/after photos.

Personally, I’ve used Mederma for my chest keloids and have seen slow but steady improvements in scar texture and color (check out my progress photos here).

Mederma has a light texture and mild scent. It’s easy to apply and dries quickly.

Key Features

  • Cepalin (onion extract)
  • Light texture
  • Mild scent
  • Dries quickly

Key Benefits

  • Softens existing scars
  • Reduces scar discoloration
  • Won’t break the bank

Suitable For

  • Hypertrophic scars
  • Keloids (including on the chest or earlobes)
  • Surgical scars (including C-section)
  • Scars from trauma, burns, or injuries
  • Scars on the face, hands, and other visible areas

Why Onion Extract?

Onion extract (allium cepa) has antioxidant and anti-inflammatory properties.

Studies show that onion extract may inhibit fibroblasts (cells that produce collagen). (3) 

This can help soften hypertrophic scars and keloids and may also reduce discoloration. 

Onion extract also contains quercetin, a plant flavonoid that inhibits collagen. (4)

The clinical evidence, however, is still inconclusive:

  • One study reported no difference between onion extract and Vaseline (5)
  • Other studies reported positive results using onion extract (6, 7, 8)
  • One study was funded by Merz (manufacturer of Mederma) (8)

Mederma Reviews

Mederma has well over 2,000 reviews on Amazon. While reviews are mostly positive, Mederma doesn’t work for everyone. 

For some people, Mederma flattened their scars completely. But for others, it didn’t seem to move the needle much.

As with all skincare products, your mileage may vary (YMMV).

Side effects of Mederma may include itchiness, irritation, and redness. 

Read my full review of Mederma here.

Pro Tip: use Mederma 2x daily (instead of 1x) to maintain continuous scar coverage.

The Bottom-Line

Mederma is a popular scar gel that works well and is quite affordable.

Alternatives to Dermatix & Mederma

My Top Pick

My top pick for a silicone gel.

Featuring 100% silicone and vitamin E, NewGel+ is a great balance of effectiveness and affordability (I use it myself).

Runner-Up

A high quality silicone gel.

Another high quality silicone gel, Kelo-Cote is effective on hypertrophic scars and keloids but a little more expensive.

For Body Scars

Best for large body scars.

Featuring 100% silicone gel, ScarAway Silicone Scar Sheets is my top pick for large scars from surgery, injury, or burns.

What Causes Scars?

Ever wonder why you get those pesky scars in the first place?

Well, research suggests that genetics are partly to blame (thanks, Mom and Dad). (3)

But scars themselves are a natural response by your body to injuries.

Part 1: Inflammation

When you’re injured, your body sets off an “alarm” signal known as inflammation.

This process jumpstarts the immune system and triggers wound healing signals.

Part 2: Repair

After inflammation comes the repair stage.

Your body replaces damaged skin with new skin cells and materials like collagen.

Collagen fibers weave together to form the foundations of new skin tissue (a “scar”).

Part 3: Scars

Unfortunately, scars are seldom identical to the original skin.

They’re often a different color and may feel hard or lumpy.

Sometimes, scars end up elevated like hypertrophic scars or keloids. 

This happens if your body produced too much collagen during the repair stage.

The Bottom-Line

I hope this guide to Mederma vs Dermatix helps you pick the right product for you. 

Remember, nothing can replace patience and consistency! 

To Recap:

If you want the best results, go for a silicone gel like Dermatix.

If you’re on a limited budget, a good alternative is Mederma.

Sources

  1. Gold MH, et al. International Advisory Panel on Scar Management. “Updated international clinical recommendations on scar management: part 2–algorithms for scar prevention and treatment.” Dermatological Surgery vol. 40,8 (2014): 825-31. https://www.ncbi.nlm.nih.gov/pubmed/25068544
  2. Bleasdale, Benjamin et al. “The Use of Silicone Adhesives for Scar Reduction.” Advances in Wound Care vol. 4,7 (2015): 422-430. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486716/
  3. Cho JW, et al. “Onion extract and quercetin induce matrix metalloproteinase-1 in vitro and in vivo.” International Journal of Molecular Medicine vol. 25,3 (2010): 347-52. https://www.ncbi.nlm.nih.gov/pubmed/20127038
  4. Phan TT, et al. “Quercetin inhibits fibronectin production by keloid-derived fibroblasts. Implication for the treatment of excessive scars.” Journal of Dermatological Science vol. 33 (2003): 192–4. https://www.ncbi.nlm.nih.gov/pubmed/14643528
  5. Chung VQ, et al. “Onion extract gel versus petrolatum emollient on new surgical scars: prospective double-blinded study.” Dermatological Surgery vol. 32,2 (2006): 193-7. https://www.ncbi.nlm.nih.gov/pubmed/16442038
  6. Ho WS, et al. “Use of onion extract, heparin, allantoin gel in prevention of scarring in chinese patients having laser removal of tattoos: a prospective randomized controlled trial.” Dermatological Surgery vol. 32,7 (2006): 891-6. https://www.ncbi.nlm.nih.gov/pubmed/16875470
  7. Beuth J, et al. “Safety and efficacy of local administration of contractubex to hypertrophic scars in comparison to corticosteroid treatment. Results of a multicenter, comparative epidemiological cohort study in Germany.” In Vivo vol. 20,2 (2006): 277-83. https://www.ncbi.nlm.nih.gov/pubmed/16634531
  8. Draelos, Zoe D et al. “A new proprietary onion extract gel improves the appearance of new scars: a randomized, controlled, blinded-investigator study.” The Journal of Clinical and Aesthetic Dermatology vol. 5,6 (2012): 18-24. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390235/
  9. Gauglitz, Gerd G et al. “Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies.” Molecular Medicine (Cambridge, Mass.) vol. 17,1-2 (2010): 113-25. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022978/
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Tom Qiao

I solve skin mysteries using simple science to provide you the best skincare advice!

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